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CORSiCA: Investigating Rectal Cancers’ Nodal Positivity Before Surgery 24/02/2017

Conceived in the framework of the EYSAC young researchers' activities, the proposal for the project CORSiCA ‘Complete pathologic response rectal cancers EYSAC.1 Study’ will investigate complete responders’ rectal cancers at the European level.

About 20% of patients with rectal cancers who received neoadjuvant treatment achieve a pathological complete response in the surgical specimen (ypT0). However, about 10% of ypT0 present metastatic nodes and, thus, the identification of surgical specimen with metastatic nodes could be crucial in order to tailor future treatments and improve their chances of cure.

Once accepted, the CORSiCA project will build a large database with the clinical, pathological and radiological data of pathologic complete responders, to study ypT0 rectal cancers in relation to the nodal status and, thus, predict the nodal positivity before surgical treatment. 

The CORSiCA proposal is currently under review by the European Research Council (ERC) as a ‘starting grant project’. After having conducted at the Italian level a retrospective multicentric study on 230 ypT0 focused on treatment and outcomes, the Research Delegate of the ESSO Young Surgeons and Alumni Club (EYSAC) Steering Committee Dr. Laura Lorenzon (Sapienza University of Rome, Italy) will be the Principal Investigator of this new project. 

ESSO will be a project partner in CORSiCA, thanks to the precious project contribution of Prof. Geerard Beets from the ESSO Education Committee (Netherlands Cancer Institute, Amsterdam), President of the Italian Society of Surgical Oncology Prof. Paolo Delrio (National Cancer Institute “Pascale Foundation”, Naples) and EYSAC Chair Dr. Karol Polom (Poland/Italy). 

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